Lethal Effect of a Heterologous Murein Hydrolase on Penicillin-Treated Streptococcus sanguis
نویسندگان
چکیده
منابع مشابه
Transformation of Streptococcus sanguis to intrinsic penicillin resistance.
A series of step-level penicillin-resistant derivatives of Streptococcus sanguis V288 (Challis) were obtained through successive genetic transformations. The DNA donor used was a laboratory-derived, penicillin-resistant multistep mutant of the recipient strain. Detection of the penicillin-binding proteins (PBPs) of wild-type and transformants revealed five major PBPs. While it was found that S....
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The response of tolerant Streptococcus sanguis and nontolerant Streptococcus mitis infections to penicillin therapy was compared in the rabbit model of endocarditis. The minimal inhibitory and bactericidal concentrations of penicillin were 0.1 and 0.1 mug/ml, respectively, for S. mitis and 0.05 and 6.2 mug/ml, respectively, for S. sanguis. Time-kill studies done in vitro with penicillin concent...
متن کاملEffect of penicillin on the adherence of Streptococcus sanguis in vitro and in the rabbit model of endocarditis.
The effect of penicillin treatment of Streptococcus sanguis in vitro, on subsequent bacterial density in the bloodstream and on cardiac valves in the rabbit model of endocarditis was studied. As experimental tools for this study, isogenic pairs of S. sanguis differing in resistance to streptomycin or rifampin were prepared by genetic transformation. Rabbits with traumatized heart valves receive...
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Abstract Background and Aim: Streptococcus sanguis is known one of the initiating agents of microbial plaque formation. In addition to the physical control of the microbial plaque, the use of mouthwashes as a chemical method to kill microorganisms is effective. Although chlorhexidine is the gold standard for the elimination of oral microorganisms, the unpleasant side effects of its long-term...
متن کاملRecombination-deficient Streptococcus sanguis.
A UV-sensitive derivative was obtained from Streptococcus sanguis Challis. The organism could be transformed with a number of small streptococcal plasmids at frequencies equal to, or 1 logarithm below, the transformation frequencies for the parent organism. However, transformation with chromosomal DNA was greatly impaired in the UV-sensitive derivative.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1980
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.17.2.235